The United States has long been at the forefront of assisted reproductive technologies. With its advanced IVF techniques, a legal and well-established egg donation and surrogacy system, and highly developed embryo genetic screening capabilities, the U.S. has brought hope to countless families around the world facing fertility challenges. During an IVF journey in the U.S., the choice of technology, clinic quality, and personalized needs—such as genetic screening or gender selection—can all significantly impact success rates.

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Overview of the Three Generations of IVF in the U.S.

The U.S. widely applies third-generation IVF, representing the most advanced developments in assisted reproduction. This generation integrates key technological upgrades at every stage—from fertilization and embryo development to genetic screening—greatly improving both success rates and birth outcomes.

 

• First-generation IVF (In Vitro Fertilization): Primarily for women with blocked fallopian tubes or other infertility issues, where sperm and egg are combined in a lab to allow natural fertilization.

• Second-generation IVF (ICSI - Intracytoplasmic Sperm Injection): Suitable for male infertility cases involving low sperm count or motility, where a single sperm is directly injected into the egg to boost fertilization chances.

• Third-generation IVF (PGT - Preimplantation Genetic Testing): Involves genetic and chromosomal screening before embryo transfer, allowing only the healthiest, most viable embryos to be selected, ensuring better pregnancy outcomes.​

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Embryo Chromosomal Screening: PGT-A

PGT-A (Preimplantation Genetic Testing for Aneuploidy) is used to assess whether an embryo has the correct number of chromosomes. This enables doctors to identify and prioritize chromosomally normal embryos for transfer, which:

• Significantly increases pregnancy success rates

• Reduces the risk of miscarriage

• Minimizes the chance of passing on chromosomal disorders

 

In the U.S., PGT-A has become standard practice in IVF and surrogacy treatments—especially beneficial for:

• Women over 35

• Those with a history of miscarriage or failed embryo transfers

• Families interested in gender selection or optimizing for genetic health

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Single-Gene Disorder Screening: PGD

PGD (Preimplantation Genetic Diagnosis) focuses on identifying specific genetic diseases or mutations within embryos. It is ideal for families with a known genetic history or where one or both partners are carriers of inherited conditions.

 

Conditions PGD can screen for include (but are not limited to):

• Thalassemia

• Cystic fibrosis

• Huntington’s disease

• X-linked genetic disorders

 

By analyzing just a few cells from a blastocyst-stage embryo, PGD ensures only healthy embryos without the targeted genetic conditions are used for implantation—dramatically reducing hereditary risk in future generations.

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Scientific Gender Selection

U.S. law permits embryo gender selection when there are medical indications or family planning needs. Using PGT-A, the embryo’s sex chromosomes (X or Y) can be identified, allowing parents to select the gender prior to embryo transfer.

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How to Choose a U.S. IVF Clinic

Success with IVF depends not just on the technology, but also on:

• The experience of the medical team

• The standards of the laboratory

• The skill of embryologists

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To make the right choice:

• Review up-to-date clinic success rates and patient reviews

• Choose a clinic with a proven record and high-quality service

• Reduce the number of embryo transfers and increase the overall efficiency of treatment

 

Low Sperm Quality? Here’s How IVF Can Help

Male infertility is a significant factor in many cases. U.S. clinics offer advanced solutions to overcome sperm-related challenges:

• ICSI (Intracytoplasmic Sperm Injection): Even with extremely low sperm count, success can be achieved by injecting a single sperm directly into the egg

• Zymot sperm selection: Uses microfluidic chips to isolate the most motile, DNA-intact sperm

• TESA (Testicular Sperm Aspiration): For men with azoospermia (no sperm in semen), viable sperm can be retrieved directly from the testes

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The U.S. has no legal age limit for male partners, meaning even older men can still achieve fatherhood.

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IVF + Legal Surrogacy Comprehensive Support for Your Family Dream

For families unable to conceive naturally, the U.S. offers a legally sound and medically advanced surrogacy system. In this process, embryos created from the intended parents’ own eggs and sperm are screened and then transferred to a surrogate, ensuring a safe and efficient path to parenthood.

• Carefully screened, experienced surrogates

• Legal, transparent contracts to protect all parties

• Full project management and continuous support throughout the journey

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From preparation to holding your baby in your arms, you can feel confident every step of the way. For more information about IVF and surrogacy in the U.S., feel free to contact the expert team at New Star Babies. We offer free initial evaluations and personalized plan recommendations to support your path to parenthood.

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